Internet Explorers

Tyler is putting Science back into the hands of the people.

In episode #56 of Internet Explorers, Jess and Josh explore the forefront of decentralized science (DeSci) with Tyler from Triplicate, unpacking how blockchain is unlocking new funding models, democratizing research, and enabling cutting-edge projects like molecular therapeutics and patient-driven clinical trials. They analyze how these decentralized approaches are breaking free from the constraints of traditional institutions and incentivizing innovation in unexpected ways.

The discussion shifts to distribution-first software, a paradigm focused on leveraging social networks and decentralized platforms to maximize reach and adoption before building standalone products. They also examine the concept of Moats in the age of AI, debating whether traditional business defensibility strategies hold up in a world of open-source models and rapidly evolving technologies. Later, they reflect on the growing presence of normies in degen crypto spaces, and the unhinged activities occurring on pump.fun (jess is scared).

The episode concludes with ai16z drama, reflecting on how it's more difficult it is to build when a token is involved.

0:00 - Intro
1:08 - Start of Episode
4:26 - DeSci
37:07 - Distribution-First Software
42:38 - Moats In The Age Of AI
49:32 - The Normies Are Here
54:48 - ai16z Drama

Internet Explorers is a weekly rundown show where extremely online individuals broadly explore (romanticize, even) new consumer internet experiences.

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